Quantitative Determination of Amlodipine Besylate, Losartan Potassium, Valsartan and Atorvastatin Calcium by HPLC in their Pharmaceutical Formulations
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چکیده
منابع مشابه
Simultaneous Determination of Amlodipine Besylate and Atorvastatin Calcium in Binary Mixture by Spectrofluorimetry and HPLC Coupled with Fluorescence Detection
Caduet tablets are novel prescription drug that combines amlodipine besylate (AM) with atorvastatin calcium (AT). A spectrofluorimetric and an HPLC-fluorescence detection methods were developed for simultaneous determination of both drugs in tablets. In the spectrofluorimetric method, native fluorescence of AM and AT were measured in methanol at 442 and 369 nm upon excitation at 361 and 274 nm,...
متن کاملDevelopment of a Stability-Indicating HPLC Method for Simultaneous Determination of Amlodipine Besylate and Atorvastatin Calcium in Bulk and Pharmaceutical Dosage Form
Copyright: © 2014 Hafez HM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Development of a Stability-Indicating HPLC Method for Simultaneous Determination of Amlodipine Besylate and Atorvastatin Calci...
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Losartan, a highly effective blood pressure lowering agent, has been widely used for the treatment of hypertension. A fast and reliable method for the determination of losartan was highly desirable to support formulation screening and quality control. A first derivative UV spectroscopic method was developed for determination of losartan in the tablet dosage form. The first derivative spectrum r...
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The bioequivalence of combination tablets containing amlodipine besylate/atorvastatin calcium with coadministered matching doses of amlodipine besylate and atorvastatin calcium tablets was investigated in randomized, 2-way crossover studies in healthy volunteers (N = 126). Subjects received a single dose of the amlodipine/atorvastatin tablet or coadministered matching doses of amlodipine and at...
متن کاملDetermination of Losartan Potassium and Perindopril Erbumine in Tablet Formulations by Reversed-Phase HPLC
The present work describes a validated reverse phase high performance liquid chromatographic method for simultaneous estimation of losartan potassium and Perindopril Erbumine in tablet formulation. Chromatography was performed on a ODS Hypersil C18 (250 mm x 4.6 mm i.d., 5 μm particle size) column with mobile phase containing Acetonitrile: Acidic Water pH 3.4 (50+50). The flow rate was 1.5 mL/m...
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ژورنال
عنوان ژورنال: Pharmaceutica Analytica Acta
سال: 2014
ISSN: 2153-2435
DOI: 10.4172/2153-2435.1000300